Region-Selective Deposition of Core-Shell Nanoparticles for 3D Hierarchical Assemblies by the Huisgen 1,3-Dipolar Cycloaddition

Sebastian H. Etschel, Luis Portilla, Johannes Kirschner, Martin Drost, Fan Tu, Priv.-Doz. Dr Hbertus Marbach, Prof. Dr. Rik R. Tykwinski, Prof. Dr. Marcus Halik Abstract Like a NP-needle in an azide-stack: Metal oxide nanoparticles functionalized with alkyne- and azide-bearing phosphonic acids were assembled in defined stacks with precise control over region-selectivity and layer composition by […]

Multifunctional magnetic nanoparticles for enhanced intracellular drug transport

C. Tudisco, M. T. Cambria, F. Sinatra, F. Bertani, A. Alba, A. E. Giuffrida, S. Saccone, E. Fantechi, C. Innocenti, C. Sangregorio, E. Dalcanale and G. G. Condorelli Abstract In this paper we report the synthesis and characterization of biocompatible multi-functional magnetic nanoparticles (MNPs) able to enhance the intracellular transport of N-methylated drugs. The Fe3O4 […]

The Purchasable Chemical Space: A Detailed Picture

Xavier Lucas, Björn A. Grüning, Stefan Bleher, and Stefan Günther Abstract The screening of a reduced yet diverse and synthesizable region of the chemical space is a critical step in drug discovery. The ZINC database is nowadays routinely used to freely access and screen millions of commercially available compounds. We collected ∼125 million compounds from […]

Smoothly Tunable Surface Properties of Aluminum Oxide Core−Shell Nanoparticles By A Mixed-Ligand Approach

Luis Portilla and Marcus Halik Abstract We present a facile solution-based procedure for tailoring the surface properties of aluminum oxide nanoparticles (AlOx-NPs) by the formation of tunable core–shell systems with self-assembled monolayers. By employing chained molecules with a phosphonic acid anchor group and either hydrophobic or hydrophilic chains the surface properties of the nanoparticles change […]