Saïd Jebors, Coline Pinese, Benjamin Nottelet, Karine Parra, Muriel Amblard, Ahmad Mehdi, Jean Martinez, Gilles Subra
Abstract
We have recently reported on a new class of silicone–peptide‵ biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.